Endocrinology and Metabolic Disorders

Obesity, Diabetes and Metabolism

Diabetes and Obesity is the most challenging health problems in the 21st century and one of the most common non-communicable diseases globally. It is the 4th or 5th leading cause of death in most high-income countries, with ~366 million diabetics in 2011 and an estimated 552 million in 2030. On the other hand, obesity has also become a world-wide epidemic. Obesity is a risk factor for the development of insulin resistance, with pancreatic beta cells compensating for insulin resistance by augmenting insulin secretion. The failure of beta-cells is believed to cause pre-diabetes, a condition that can lead to diabetes". Approximately 85% of people with diabetes are type 2, and of these, 90% are obese or overweight. Diabetes & obesity are major contributors to various other chronic diseases such as coronary artery diseases, myocardial infarction, hypertension, dyslipidemia and a number of other complicated disorders