Runa A, Liangzhi Xu
West China Second Hospital, Sichuan University, Chengdu 610041, China
Title: The efficiency and safety of traditional Chinese herbal medicine Kun Tai in treatment of premature ovarian insufficiency：a meta-analysis
Biography
Biography: Runa A, Liangzhi Xu
Abstract
To systematically review the efficacy and safety of traditional Chinese herbal medicine Kun Tai in the treatment of premature ovarian insufficiency. Methods　PubMed, EMbase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on Kun Tai used for treating premature ovarian insufficiency from inception to August, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software. Results　 Twenty-one randomized controlled trials were included. The results of meta-analyses showed that: effective rate (RR=2.78, 95%CI 1.73 to 4.45, P<0.000 01), the change of Kupperman`s score (MD=-3.25, 95%CI -3.75 to -2.76, P<0.000 01), the change of serum FSH (MD=-6.99, 95%CI -8.07 to -5.90, P<0.000 01), E2 (MD=6.38, 95%CI 5.64 to 7.11, P<0.000 01) and LH (MD=-4.66, 95%CI -6.45 to -2.86, P<0.000 01) in Kun Tai combined with hormone replacement therapy (HRT) group were higher than that in the HRT group. Conclusion　 Kun Tai combined with HRT are better than HRT alone in the effective rate, the change of Kupperman`s score, the change of serum FSH, E2 and LH for patients with premature ovarian insufficiency. Due to limited quality and quantity of the included studies, more high-quality studies are required to verify above conclusion.