Priya.D.Alva
K.S Hegde Medical Academy, Deralakatte
Title: Associations of Sex Hormone Binding Globulin and Free Testosterone concentration in Postmenopausal women with Type 2 Diabetes Mellitus.(Poster Presentation)
Biography
Biography: Priya.D.Alva
Abstract
Introduction: Sex Hormone Binding Globulin (SHBG) is a glycoprotein secreted by the liver into the bloodstream. The principal function of SHBG is to transport the sex steroids mainly androgen and estrogen. Hyper insulinemia and insulin resistance is thought to play an important role in the inhibition of SHBG there by increasing the androgen concentration leading to hyper androgenicity.
Aim : To find the association of SHBG and free testosterone levels in postmenopausal women with type 2 diabetes mellitus.
Research design and methods: It is a case control study. 105 postmenopausal women with type 2 diabetes mellitus and 85 control subjects were recruited from the outpatient department of K.S Hegde Charitable Hospital, Deralakatte, Mangalore. Anthropometric variables, SHBG, steroid hormones, insulin and the degree of insulin resistance were measured among case and control women.
Results: Women with type 2 diabetes mellitus had significantly higher insulin [21.4 (3.02, 30.9 µIU/mL) p value<0.001), lower SHBG [20.65 (12.54, 33.46 nmol/l)]p value<0.05 and higher free testosterone [0.0245 (0.011, 0.03nmol/l) p value<0.05 than the control. SHBG correlated negatively with insulin, insulin resistance and free testosterone.
Conclusion: Low levels of SHBG are observed in type 2 diabetic postmenopausal women with higher insulin resistance and free testosterone. Thus, reduced SHBG in postmenopausal women with type 2 diabetes mellitus can be correlated with insulin resistance and hyperandrogenecity.