Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

11th World Congress on Endocrinology and Metabolic Disorders

Auckland, Newzealand

Hyun-Chul Kim

Hyun-Chul Kim

E & M Psychiatry Clinic, Daegu, Republic of Korea

Title: Dysthyroidism : Is This One of Suicide Squads?

Biography

Biography: Hyun-Chul Kim

Abstract

Dysthyroidism : Is This One of Suicide Squads?

INTRODUCTION 

For a decade S. Korea has the highest suicide rate among OECD countries even with fabulous medical check-ups and insurances. But unfortunately, Thyroid Function Test(TFT) has not been included in routine check-ups. Even if asked, blood sampling and follow-up are relatively ignored compared with expensive ultrasonography to rule out cancer, which threatens everyone. Many symptoms of the psychiatric disorder are known to have interfered with by dysthyroidism. But in the case of subclinical dysthyroidism, treatment strategies are controversial. We’ve found how many psychiatric outpatients are suffered from subclinical dysthyroidism and their relation with autonomic nervous system activity and clinical improvement

Partial Corr

Correlations

 

 

 

 

 

 

 

 

 

 

Control Variables

 

 

TP

S

P

B

 

ABN

AGE

TP

Correlation

1.000

.876

.816

.066

 

.141

 

 

Significance (2-tailed)

.

.000

.000

.335

 

.039

 

 

df

0

212

212

212

 

212

 

S

Correlation

.876

1.000

.666

.393

 

.069

 

 

Significance (2-tailed)

.000

.

.000

.000

.313

 

 

df

212

0

212

212

212

 

 

 

 

 

 

 

 

 

P

Correlation

.816

.666

1.000

-.398

.112

 

 

Significance (2-tailed)

.000

.000

.

.000

.101

 

 

df

212

212

0

212

212

 

 

 

 

 

 

 

 

 

B

Correlation

.066

.393

-.398

1.000

-.056

 

 

Significance (2-tailed)

.335

.000

.000

.

.415

 

 

df

212

212

212

0

212

 

 

 

 

 

 

 

 

 

ABN

Correlation

.141

.069

.112

-.056

1.000

 

 

Significance (2-tailed)

.039

.313

.101

.415

.

 

 

df

212

212

212

212

0

METHODS

The 335 outpatients in this study were recruited and 244 subjects who meet diagnostic criteria of Schizophrenia spectrum disorder, Affective spectrum disorder, Panic disorder. Heart Rate Variability(HRV) Tests and blood sampling to check Thyroid hormone were performed to all patients, both of which results are not interfered by any intention. Clinical Global Improvement Scale was used to know the effect of thyroid treatment in subclinical dysthyroidism. Descriptive statistics were used to check how many patients recognized dysthyroidism for the first time and ANCOVA was used to evaluate the differences between the euthyroid and dysthyroid group in symptoms and autonomic nerve system activities. Partial correlation and Multiple regression analysis were conducted to determine thyroid hormone as a predictive value.

RESULTS

20.93% of psychiatric outpatients are turned out to have dysthyroidism : Which means nearly 21 of 100 people visit psychiatry clinic are in an abnormal thyroid function state.


 

Regression   Variables      Entered / Removed

Model        Variables Entered        Variables Removed        Method

1

ABN

.

Enter

 

 

 

a. All requested variables entered.

b. Dependent Variable : TP

Model Summary

 

 

Model

R

R Square

Adjusted R Square

Std. Error of the Estimate

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1

.140

.020

 

.015

.99216

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

a. Predictors : ( Constant ), ABN

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANOVA

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Model

Sum of Squares

df

Mean Square

 

F

 

 

Sig.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1

Regression

4.209

 

 

1

 

4.209

4.275

 

 

 

 

.040

 

 

 

 

Residual

209.673

 

213

.984

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Total

213.882

 

214

 

 

 

 

 

 

 

 

 

 

 

 

a. Predictors: ( Constant ), ABN

 

 

 

 

 

 

 

 

 

 

 

 

 

 

b. Dependent Variable : TP

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Coefficients

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Model

Unstandardized

 

 

Standardized

 

 

 

 

 

 

 

 

 

 

Coefficients

 

 

Coefficients

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

B

 

Std. Error

 

Beta

 

t

 

 

 

 

Sig

 

 

 

1

( Constant)

6.669

 

.076

 

 

 

 

87.646

 

 

 

 

.000

 

 

 

ABN

.344

 

.166

 

 

.140

 

2.068

 

 

 

 

.040

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

a. Dependent Variable : TP

CONCLUSION

CGI score (not shown above) in dysthyroid group after administration of T4 showed significant improvement (p<0.01),   especially co-morbid addiction pathology with panic disorder and with Depressive disorder. This Study has successfully proved via HRV test that Thyroid Hormone, which relates with oxidative stress and neuronal degeneration, can be one of major predictive factors in planning treatment strategy and assuming prognosis. Repeated multi-centered study will be required to validate this result, so as to be one of references in planning national suicide prevention program.

 

 

 

 

 

HyunChul Kim, [email protected]