Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 12th World Congress on Endocrinologyand Metabolic Disorders Bangkok, Thailand.

Day 1 :

Keynote Forum

Ali A Mustafa

Ph.D., Mohamed Abukahter, FRCS Arjmand Reyaz MS (General Surgery)

Keynote: The influence of Sleeve Gastrectomy on the Levels of Gut Peptides in obese diabetic and obese non-diabetic patients

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Ali A Mustafa  photo
Biography:

Ph.D. – 1982

Doctoral student in Neuropharmacology at the University of Southampton, England.

M.Sc. – 1979

Postgraduate student at Southampton University studying Biochemical Pharmacology

B. Pharm. - 1973 

1973 Faculty of Pharmacy, University of Khartoum for the Degree of B. Pharm.

Professor of Clinical Pharmacology & Therapeutics in the College of medicine at king Fahad Medical City -2007-2019 

Abstract:

Objective: Our primary goal in conducting this prospective study was to investigate and analyze the influence of sleeve gastrectomy on the blood levels of gut peptides; ghrelin, peptide YY (PYY), Glucagon-like Peptide-1 (GLP-1), and leptin in Type-2 diabetic and non-diabetic morbidly obese (MO) patients. And, also, to examine changes in tissue levels of these gastrointestinal hormones in diabetic and non-diabetic individuals at the time of Laparoscopic sleeve gastrectomy (LSG) 

Methods

Fasting blood levels of the above peptides and metabolic indices of glucose metabolism were evaluated in 30 consecutive morbidly obese non-diabetic and 29 morbidly obese diabetic subjects before and six months after LSG. The tissue levels of the peptides were determined only before surgery for both groups.

Results:

The BMI values decreased noticeably at six  An improvement in the overall glycemic profile of the morbidly Obese (MO) patients was observed. The fasting blood levels of ghrelin and leptin were decreased, following LSG. On the other hand, however, the blood levels of PYY and GLP-1 were significantly increased, postoperatively.

Conclusions:

LSG improves glucose homeostasis, significantly. It, also, produced significant changes in the blood levels of ghrelin, PYY, GLP-1 and leptin in both the MO diabetic or the MO non-diabetic paints. The tissue levels of the peptides, at time of surgery, were also noticeably affected. These hormonal changes may have multiple beneficial effects on the mechanisms underlying weight loss and the control of   diabetes.prospective study

Keynote Forum

Luo yunyao, Sichuan University, China

Sichuan University, China

Keynote: The role of irisin in postmenopausal osteoporosis

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Luo yunyao, Sichuan University, China photo
Biography:

Luo yunyao has been learning a PhD in Gynecology and has been a member of the Joint Laboratory for Reproductive Medicine of Sichuan University–The Chinese University of Hong Kong since 2016. She mainly studies various female infertility, reproductive endocrine diseases including: menstrual disorders, amenorrhea, polycystic ovary syndrome, menopause and menopausal syndrome, abnormal sexual differentiation, children gynecological diseases. Her current research is focus on the osteoporosis in postmenopausal women and in order to search for the specific protein for therapeutic application of in postmenopausal osteoporosis.

 

 

Abstract:

Osteoporosis is a major healthcare burden that affects mainly postmenopausal women and is characterized by compromised bone strength and increased risk of fragility fracture. Exercise has a positive effect on prevention of postmenopausal osteoporosis fractures. Irisin, a novel myokine that was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise on bone tissue. Some studies have shown that irisin can promote osteoblast proliferation and differentiation, inhibit osteoclast differentiation and increase bone mass. This study aims to evaluate the effects of irisin on bones of ovariectomized (OVX) mice, to explore a possible treatment for postmenopausal osteoporosis. Thirty-six mice were randomly assigned to three groups: OVX with r-irisin, OVX with saline and sham with saline. After 5 weeks of injection, they were sacrificed, and the trabecular bone structure of the femur, bone strength of the tibia and serum parameters were assessed. Treatment with r-irisin prevented trabecular bone loss and enhanced bone strength in the bone metaphysis of the OVX mice. The r-irisin-treated OVX mice exhibited a significant increase in bone mineral density, bone volume to tissue volume ratio, connection density, and trabecular number compared to those of the saline-treated OVX mice, which showed increased bone stiffness. Consistently, OVX mice treated with r-irisin showed decreased bone resorption markers such as osteoclasts and increased osteogenic markers such as osteoblasts. Moreover, r-irisin treatment significantly increased serum osteocalcin levels compared to saline-treated OVX mice. Therefore, our study extended the understanding of the role of irisin in bone metabolism and revealed the possibility of therapeutic application of irisin for postmenopausal osteoporosis.

 

Keynote Forum

Muhammad Asif Rasheed,

COMSATS University Islamabad, Sahiwal Campus, Pakistan

Keynote: Title:Inhibition of 2C Coxsackie B virus protein to decrease pathogenicity of diabetes mellitus Type1

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Muhammad Asif Rasheed, photo
Biography:

Dr. Muhammad Asif Rasheed has his expertise in bioinformatics approaches and passion in improving the health and wellbeing. He recently completed PhD studies from Huazhong Agricultural University, Wuhan, China and applied different bioinformatics approaches to predict the virulence factors in Mycoplasma bovis bacteria. Simultaneously he published review articles by applying different bioinformatics tools on proteins related to liver cirrhosis. Recently he is working on virulence factors related to Diabetes mellitus type 1.

 

Abstract:

Type 1 diabetes mellitus is one of the most common disease in different area of world now a days. Enterovirus infections have been implicated in the development of the disease. The viral protein 2C Coxsackie is thought to be responsible for destruction of beta cells in pancreas. The blocking of 2C Coxsackie can be a milestone to decrease pathogenicity of the disease. By using different bioinformatics tools and databases, there is a need to design an inhibitor against virulence protein of diabetes. We developed an inhibitor based on different In silico approaches. This work will help researchers to get an idea about the understanding of chemicals against Coxsackie B4 viruses and helpful for researchers to test these chemical as a drug to overcome Diabetes Mellitus Type1 due to coxsackie B4 virus.

 

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker THANH HOANG photo
Biography:

Dr Hoang’s early experiences in Vietnam and his health-related work throughout the years have cultivated virtues of compassion, commitment and understanding, which provide him with a strong foundation for a career in Internal Medicine.  

 

Dr. Hoang earned his Bachelor of Science degree in Biochemistry and graduated with cum laude from the University of Maryland, College Park.  He received his medical degree from Lake Erie College of Osteopathic Medicine in 2004 and completed his internship and residency training at the National Naval Medical Center (NNMC), Bethesda, Maryland in 2007. 

 

Dr Hoang had served as a staff internist at the U.S. Naval Hospital Yokosuka, Japan from 2007-2009 and received a Teacher of the Year award 2008- 2009.  Dr Hoang completed his fellowship training at NNMC and is board certified in endocrinology, diabetes and metabolism.  He served as a staff endocrinologist at National Naval Medical Center (2011-2012) and at Naval Medical Center Portsmouth (2012-2013).  He served as Service Chief, Endocrinology and Metabolism Division and Diabetes Champion at the Naval Medical Center San Diego (2013-2016) and Associate Professor in medicine, Uniformed Services University of the Health Sciences.  He is a Fellow of the American College of Physicians and the American College of Endocrinology. He has authored a variety of publications, including peer-reviewed articles, letter to the editor, and book chapters.  He was recognized as “Associate Master Clinician Award” (2014) from Naval Medical Center San Diego.  He came back to Walter Reed National Medical Center, Bethesda in November 2016 to join the Endocrinology clinic here and to serve as the National Capital Consortium Endocrinology Fellowship Program Director.

 

Abstract:

Case Presentation:

A 43-year-old woman presents to discuss continuous glucose monitor (CGM) technologies.  She has type 1 diabetes mellitus diagnosed at age 14 and has been on insulin pump since 2001 which was upgraded to MedtronicTM 630G in July 2017.  She has adequate glycemic control (A1c 7.3%), but finger-stick blood glucose levels fluctuate widely with occasional hypoglycemia.  Past surgical history was noncontributory.  She exercises regularly, walking 30 minutes several times per day with a goal of 7000 steps per day.  She tried to use a CGM in 2018 (Medtronic) but she discontinued the CGM due to frequent alarms.  Patient reports the alarms were not due to highs or lows, but due to difficulty with obtaining accurate readings.  Patient consulted an endocrine clinic to improve blood glucose monitor with new CGM technology.  Patient subsequently developed bilateral arm pain intermittently for which primary care provider ordered X-ray of both arms which shows the EversenseTM sensor and transmitter on the right arm and the sensor alone on the left arm (Fig 1-2).

CGM devices measure the glucose level of interstitial fluid which correlate well with plasma glucose.  Glucose levels are measured every 5-15 minutes, depending on the device.  The EversenseTM sensor (Fig 1-2) is placed in the upper arm by a physician.  Once inserted, it continuously measures glucose levels for up to 3 months.  The EversenseTM smart transmitter sits over the sensor on the upper arm.  The transmitter is water-resistant, rechargeable, and can be easily removed.  Not only can the transmitter can send data to the EversenseTM Mobile App but it can also provide on-body vibration alerts when glucose level fluctuates high or low.  The EversenseTM Mobile App receives and displays the data easy-to-read charts and graphs, making it easy for patients to monitor their blood glucose.  The difference between EversenseTM CGM system compared to other CGM devices are that (a) there is no weekly sensor self-insertion since EversenseTM CGM lasts up to 3 months, (b) sensor is placed under the skin; thus, no concern about it falling off, (c) no separate receiver is required; data, trends and alerts can be viewed on mobile device; (d) highs and lows can be detected quickly.  Many CGM devices allow patients to share their blood glucose data in real time with friends, relatives, and caregivers using a smartphone app, which may be particularly important when patients have hypoglycemia.  The case demonstrates an interesting radiological finding of an implantable CGM sensor, and also the importance of awareness of various CGM systems with different safety advantages to improve diabetic care.

ACKNOWLEDGMENT

The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of the Navy, Department of Defense, or the U.S. Government.

 

DISCLOSURE

The authors have no multiplicity of interest to disclose.

 

Keynote Forum

Mohamed K.M. Shakir

Division of Endocrinology, Department of Medicine

Keynote: ADRENAL HEMORRAGE SECONDARY TO ANTIPHOSPHOLIPID SYNDROME CAUSING ADRENAL INSUFFICIENCY

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Mohamed K.M. Shakir photo
Biography:

Dr  Mohamed Shakir MD,MACP,MACE,FRCP, FACN,ECNU , is presently Professor  of Medicine, Uniformed  University of Health Sciences , Bethesda, MD and staff endocrinologist in the Dept., of  Walter Reed National Medical Center. I  received my MD degree from All India Institute of Health Sciences, New Delhi and completed residency in Internal Medicine at the University  Hospital, New Hersey College of Medicine , Newark, NJ  and  was followed by a fellowship in Endocrinology, Johns Hopkins Hospital , Baltimore ,MD . After completing fellowship I remained at Johns Hopkins as a faculty member and subsequently joined US Navy. I rose through the rank of LCDR to Captain and was Endocrinology Department Head, Program Director and Specialty Leader for Endocrinology, US Navy for 16 years. After spending 6 months at Howard University as the Dept. Head, Endocrinology I returned to Walter Reed National Medical Center as civilian. During my Navy career I received Navy Commendations Medals, Navy Meritorious Service Medal, Navy Antarctica Medal, and National Science Foundation Service medal. I was the past President of Mid- Atlantic Chapter of American Association of Clinical Endocrinology, and Chair Person for Abstract Committee of American Association of Clinical Endocrinology. I am also Master of the American College of Physician, Master of the American Association of Clinical Endocrinology, Fellow of the Royal College of Physicians and Fellow of the American College of Nutrition. My earlier research areas involved signal traction and enzymology but for the last several years I am involved in clinical research in thyroidology.  I have published more than 200 papers in peer reviewed journals.

 

Abstract:

Objective: Antiphospholipid Syndrome (APS) can involve multiple organ systems but endocrine manifestations are rare. In most cases adrenal insufficiency (AI) is the first endocrine manifestation of APS.  The prompt diagnosis of adrenal insufficiency is critical as adrenal insufficiency is a life-threatening disease that may lead to fatal outcomes if left untreated. We present a case of AI associated with antiphospholipid syndrome who was managed successfully.

Methods: A literature search was conducted using the databases PubMed and Google Scholar for diagnosis and management of adrenal insufficiency associated with antiphospholipid syndrome.

Results: We describe a 50-year-old male presenting with deep venous thrombosis and pulmonary embolism treated with heparin. The patient subsequently developed hypotension and worsening bilateral flank pain leading to a final diagnosis of adrenal hemorrhage during the course of his hospitalization. Adrenal insufficiency was diagnosed based on serum cortisol and ACTH levels.

Conclusions: In all cases of adrenal hemorrhage and infarction with unknown etiology, screening with lupus anticoagulant and anticardiolipin antibodies is imperative. Recognition of this high mortality condition will allow for appropriate screening and confirmatory tests leading to prompt diagnosis and timely management.

 

 

Keynote Forum

Emmanuel NDIKUBWAYO

Department of Internal Medicine, School of Medicine, University of Rwanda, Kigali, Rwanda

Keynote: Prevalence of macrovascular disease and associated risk factors in diabetic patients, in Rwanda

Time : 3

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Emmanuel NDIKUBWAYO  photo
Biography:

Abstract:

Background:

Little is known about the prevalence of macrovascular disease in diabetic patients, in Rwanda.No any study done before on macrovascular disease. The aim of our study was to determine the prevalence of macrovascular disease and It associated risk factors, in rwandan diabetic patients.

Method:

This study was cross-sectional that was undertaken to evaluate the prevalence of macrovascular disease and associated risk factors among diabetic patients, at Kigali University Teaching Hospital and Butare University Teaching Hospital . We enrolled adult diabetic patients who attended the outpatient departments, from 2018-2019.

For every patient we did twelve lead electrocardiograms and It was done at initial enrollment time and interpreted using Manual Minnesota code (2) .Ankle Brachial Index was calculated using measurements from automated calf sphygmomanometer and every participant was clinically assessed , for the presence of cerebrovascular disease, basing on the WHO Monica criteria (3) .

Results: Features of macrovascular disease were found in 32 (21.7%) of the 147 patients: the most common being cerebrovascular disease with 15.6% ,followed by Peripheral Artery Disease 8.2% ,then coronary heart disease with a prevalence of 2%. The variables associated with cerebrovascular disease were: Gender, being male[p-value 0.02] and presence of coronary heart disease [p-value 0.014 ( 95%CI) ]

Peripheral vascular disease was associated with Duration of diabetes [ p-value 0.017 (95%CI)], tobacco smoking [p-value 0.02 ( 95%CI) ],elevated level of total cholesterol [ p-10 value 0.009( 95%CI)] and elevated level of LDL [ p-value 0.024( 95%CI)] while Coronary Heart Disease was significantly associated with elevated levels of triglyceride [ p-value0.027 ( 95%CI)] and the presence of cerebrovascular disease[ p-value0.014 ( 95%CI)].

CONCLUSION: Macrovascular disease is common in adult diabetic patients, in Rwanda. We need to elaborate a clear protocol on prevention and management of macrovascular disease,in diabetic patients.

 

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Firda Muthia Elsyanty photo
Biography:

Firda Muthia Elsyanty is a General Practitioner at the Sumedang General Hospital, West Java, Indonesia. She was graduated from Faculty of Medicine of Padjadjaran University in 2017 and obtained her Medical Doctor degree. She is an active member of the Indonesian Doctors Association. She is actively participating in local and national symposiums and workshops. In addition to her clinical experience, she attended clinical practice training in Department of Vascular and Endovascular Surgery of the University Hospital Heidelberg, Germany at 2017. In her spare time, she enjoys traveling, photography and spending time with her family.

Abstract:

Background: Obesity is strongly related to the increase of blood glucose level hence identified as a predictor of metabolic disease such as Type 2 Diabetes Mellitus. However, the obesity measurement parameters to predict blood glucose level still vary. The aim of this study is to investigate whether waist circumference (WC) or body mass index (BMI) is the best predictor of blood glucose level among healthy adult.

Method: An observational analytic study with cross sectional design was conducted in this study. Participants were 172 men (n=8) and women (n=164) with mean age 47,9 ± 11,0 years old. WC and BMI were identified from anthropometric measurement. Pearson correlation test was performed to quantify the correlation between obesity measurement parameters (WC and BMI) and blood glucose level.

Results: Both WC and BMI were significantly and positively correlated with blood glucose level. WC had stronger correlation to the blood glucose level (r = 0.482) compared to BMI    (r = 0.241)

Conclusions: WC is a stronger predictor of blood glucose level when compared with BMI among healthy adults.

 

Keynote Forum

Runa A, Liangzhi Xu

West China Second Hospital, Sichuan University, Chengdu 610041, China

Keynote: The efficiency and safety of traditional Chinese herbal medicine Kun Tai in treatment of premature ovarian insufficiency:a meta-analysis

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Runa A, Liangzhi Xu photo
Biography:

From Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, China, medical student of 8-year program, major in Gynaecology &Obstetrics, focus on the environmental teratogenic factors and their effects on reproduction techniques including preimplantation genetic diagnosis and conservation of female fertility, such as oocyte freezing, ovulation, embryo freezing and in vitro maturation of oocytes.

  Published several papers at home and abroad, made poster presentation and oral presentation in several congresses.

 

Abstract:

  To systematically review the efficacy and safety of traditional Chinese herbal medicine Kun Tai in the treatment of premature ovarian insufficiency. Methods PubMed, EMbase, The Cochrane Library, CBM, CNKI, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials (RCTs) on Kun Tai used for treating premature ovarian insufficiency from inception to August, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software. Results  Twenty-one randomized controlled trials were included. The results of meta-analyses showed that: effective rate (RR=2.78, 95%CI 1.73 to 4.45, P<0.000 01), the change of Kupperman`s score (MD=-3.25, 95%CI -3.75 to -2.76, P<0.000 01), the change of serum FSH (MD=-6.99, 95%CI -8.07 to -5.90, P<0.000 01), E2 (MD=6.38, 95%CI 5.64 to 7.11, P<0.000 01) and LH (MD=-4.66, 95%CI -6.45 to -2.86, P<0.000 01) in Kun Tai combined with hormone replacement therapy (HRT) group were higher than that in the HRT group. Conclusion  Kun Tai combined with HRT are better than HRT alone in the  effective rate, the change of Kupperman`s score, the change of serum FSH, E2 and LH for patients with premature ovarian insufficiency. Due to limited quality and quantity of the included studies, more high-quality studies are required to verify above conclusion.

 

Keynote Forum

Amena Aidibi

Lebanese University- Faculty of Pharmacy, Lebanon

Keynote: Assesment of quality of life amonge type 2 diabetes patients and its associated risk factors

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Amena Aidibi photo
Biography:

Amena Aidibi, Master 2 Research in Clinical Pharmacy and Pharmacoepidemiology, PharmD Clinical  Pharmacy, Lebanese University Faculty of Pharmacy

Director of this thesis: Amal Al-Hajje, Professor and instructor of  Clinical  Pharmacy, Chair of

clinical pharmacy Masters program, Chair of PharmD Clinical Pharmacy,  Lebanese University-  Lebanon

 

Abstract:

          Diabetes is a growing problem worldwide where its incidence and prevalence are increasing at an alarming rate. Its association with several comorbidities is common, making patients more susceptible to drug related problems (DRP). As a consequence, DRPs may affect patients quality of life (QoL) and may increase their morbidity and mortality risk. The objective of this study was to assess QoL and the impact of DRPs on it. A cross-sectional study was conducted among T2D patients who were attending a tertiary care teaching hospital, Lebanon.  Data was collected from medical files and patient interview. The identification DRPs were based on the Pharmaceutical Care Network Europe tool version 8.03. The QoL was assessed using Health Related Quality of Life Brief Clinical Inventory. Data was analyzed using SPSS version 23.  The total number of DRP was 313 with a mean of 2.05±1.03 per patient. The most common DRPs encountered were adverse drug event (31.3%), untreated symptoms or indication (10.54%), effect of drug treatment not optimal (7.34%) and high drug dose (7.34%). The average QoL was 40 ± 9.900.  Linear regression showed that problems ”effect of drug treatment not optimal, untreated indication, adverse drug event and Patient uses unnecessary drug” were associated with poor QoL score, while “Incomplete drug treatment was associated with better score.  Proper therapy management is necessary to prevent progression and occurrence of DRPs, for a better QoL in diabetes patients.

 

Keynote Forum

Diana Colleen M

MD St Luke’s Medical Center, Philippines

Keynote: An Unusual Case of Symptomatic Hypercalcemia from Graves’ Disease in a young Filipino female

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Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Diana Colleen M photo
Biography:

Abstract:

Hypercalcemia in hyperthyroidism is usually asymptomatic, and related to a concurrent primary hyperparathyroidism. In this report, we describe a case of symptomatic hypercalcemia secondary to Graves’ disease alone. Case Report. A 24-year-old Filipino female presented to the emergency department with generalized weakness, vomiting and abdominal pain. No other symptoms were noted. She was otherwise previously healthy. Family history was unremarkable. During physical exam, she was noted to have a non tender palpable thyroid gland without bruit. Her ECG showed sinus tachycardia. The complete blood count and electrolytes were normal however, ionized calcium was high at 1.6mmol/L (NV 1-1.3). Renal function was normal. Hydration with saline and Furosemide 20mg once daily was started though calcium levels remained elevated. Other causes of hypercalcemia were excluded as PTH was appropriately suppressed (8.8ng/L; NV 14-72), vitamin D was also suppressed (15.29 nmol/LNV: >30). CT scan of chest and abdomen and bone scan did not point to any underlying malignancy nor metabolic bone disease. Medication history was also unremarkable. She was hyperthyroid with a suppressed thyroid stimulating hormone level of 0.004pmol/L (NV:0.55-4.78), free T3 of >20pmol/L (NV:2.3-4.2), free T4 of 8.4pmol/L (NV:0.89-1.76). Thyroid receptor antibody levels were raised at 41.07 (NV:<1 kU/L). supporting the diagnosis of Graves’disease. She was started on propylthiouracil 50mg four times daily, along with propranolol 40mg three times daily. She was subsequently seen after two weeks with normal repeat calcium level and thyroid function tests. Conclusion. This report aims to highlight that thyroid disease should always be considered as a cause of hypercalcemia. A concomitant primary hyperparathyroidism should be investigated. The definitive treatment for the hypercalcemia is correction of thyroid function.

 

Keynote Forum

Mehdi Jalali

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Keynote: Assessment of hypothyroidism on laminin α5 and collagen IV disorder synthetize in mouse seminiferous tubules

Time : ORP-03

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Mehdi Jalali photo
Biography:

Abstract:

Introduction: There is evidence that extracellular matrix (ECM) components have profoundly impact on testis development, function and spermatogenesis. Hypothyroidism can negatively affect the basement membrane (BM) protein molecules and affect reproduction in the hypothyroid animals.  The aim of this study was to investigate the effects of hypothyroidism on laminin α5 and collagen IV changes in BM seminiferous tubules.

 Methods: 20 male mice were randomly divided into: 1) control group without any intervention, treated group with 0.05% propythiouracil (PTU) in drinking water for 2 months. After that, the left testicles were used for Real-Time PCR and the right specimens were used for immunohistochemistry staining methods.

 Results: In this study, it was observed that hypothyroidism could increase significantly laminin α5 and Collagen IV mRNA expression. Moreover, Immunoreactivity had a significant increase in the PTU-treated in compared to control group.

Conclusion: These data indicate that hypothyroidism may induce abnormal changes in BM key proteins of seminiferous tubules such as collagen IV and laminin.

 

Keynote Forum

Mohammad Reza Nikravesh

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Keynote: Dysregulation Collagen IV and laminin α5 in seminiferous tubules of diabetic mice

Time : ORP-04

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Mohammad Reza Nikravesh photo
Biography:

Abstract:

Introduction: Diabetes is associated with reproductive impairment on the male reproductive system and causes complications such as testosterone decreasing and infertility. Extracellular matrix (ECM) molecules are involved in testicular development and spermatogenesis, laminin and collagen IV are key proteins in seminiferous tubule basement membrane (STBM) which can play an important role in spermatogenesis. In the present study was to investigate the effect of experimental diabetes on collagen IV and laminin α5 expression in mice testis.

Materials and methods: 40 Mice C57BL/6 were divided randomly into 4 groups: 1) treated mice with 50 mg/kg Streptozotocin (STZ) intraperitoneally for 5 days continuously, 2) treated mice with STZ + insulin, 3)control without intervention, 4)sham group that received citrate buffer. After 8 weeks, Left testes of all specimens were used for Real-Time PCR and right side were applied for immunohistochemical tracing methods.

Results: Immunoreactivity and gene expression of laminin α5 and collagen IV in the STBM showed a significant increase in diabetic mice in comparison to other groups (P<0.05).

Conclusion: Diabetes is likely to cause laminin α5 and collagen changes in the STBM of seminiferous tubules.

 

Conference Series Endocrinology Congress 2019 International Conference Keynote Speaker Priya.D.Alva photo
Biography:

Mrs Alva has completed her Master degree in Medical Biochemistry from Manipal University in the year 2009. Currently she is a Research Scholar from K.S Hegde Medical Academy, Mangalore.

 

Abstract:

Introduction: Sex Hormone Binding Globulin (SHBG) is a glycoprotein secreted by the liver into the bloodstream. The principal function of SHBG is to transport the sex steroids mainly androgen and estrogen. Hyper insulinemia and insulin resistance is thought to play an important role in the inhibition of SHBG there by increasing the androgen concentration leading to hyper androgenicity.  

Aim : To find the association of SHBG and free testosterone levels  in postmenopausal women with type 2 diabetes mellitus.

Research design and methods: It is a case control study.  105 postmenopausal women with type 2 diabetes mellitus and 85 control subjects were recruited from the outpatient department of K.S Hegde Charitable Hospital, Deralakatte, Mangalore. Anthropometric variables, SHBG, steroid hormones, insulin and the degree of insulin resistance were measured among case and control women.

Results: Women with type 2 diabetes mellitus had significantly higher insulin [21.4 (3.02, 30.9 µIU/mL) p value<0.001), lower SHBG [20.65 (12.54, 33.46 nmol/l)]p value<0.05  and higher free  testosterone [0.0245 (0.011, 0.03nmol/l) p value<0.05 than the control. SHBG correlated negatively with insulin, insulin resistance and free testosterone.

Conclusion:  Low levels of SHBG are observed in type 2 diabetic postmenopausal women with higher insulin resistance and free testosterone. Thus, reduced SHBG in postmenopausal women with type 2 diabetes mellitus can be correlated with insulin resistance and hyperandrogenecity.