Day 2 :
- Thyroid Disorders | Advancements in Treatment & Prevention | Thyroid Cancer | Endocrinology & Diabetes
Location: Wink @ Naumi Hotel Auckland Airport
Christo John Frederick Muller
Biomedical Research and Innovation Platform, South Africa
Arsi University, Ethiopia
Title: Comparison of nutritional status and associated factors of lactating women between lowland and highland communities of district raya, alamata, southern tigiray, ethiopia
Time : 09:30-10:45
His expertise in public health and community nutrition and teach human nutrition at higher educational institute in Arsi University, college of health sciences, department of public health.
The Ethiopian regions have a relatively higher prevalence of under-nutrition are found in the lowlands of the country, with the exception of the highlands of Tigiray, where under-nutrition is also prevalent. A community based comparative cross-sectional study design was conducted from January 27- March 7, 2014. Sample size was determined by two population estimation formula. The total calculated sample size was 456. A stratified sampling technique was used to stratify the study area to highland and lowland. Study participants were selected by simple random sampling technique. Data were collected using anthropometric measurements and structured questionnaire. The raw data were entered and analyzed using SPSS version 20.0. Multivariable Logistic regression was done to determine the association between explanatory variable with Chronic Energy Deficiency (CED) using Body Mass Index (BMI), by computing odds ratio at 95% confidence level. A P – value < 0.05 was considered as statistically significant. The prevalence of CED of lactating mothers from lowland and highland was 17.5% and 24.6% respectively: age, husband occupation, taking vitamin A immediately after delivery or within the first eight weeks after delivery and consumption of extra food during lactation time were factors associated with chronic energy deficiency for lowland lactating women whereas parity, number of meals per day and household consumption of iodized salt were factors associated with CED for highland lactating women. CED in both comparative studies was a serious public health problem. As it is known food security does not mean nutritionally secured, Therefore, the need to develop nutrition intervention such as nutrition security programs to address under-nutrition in the study area is significant, as it was found food secured participants were slightly vulnerable than food insecure. The dietary diversity score of the participants were very low so that encourage the community about nutrition diversification is substantial for adequate nutrient intake
Time : 11:00-11:30
Tika Ram Lamichhane is Assistant Professor at Central Department of Physics (CDP), Tribhuvan University (TU), Kathmandu, Nepal. He has expertise in biomedical applications of physics particularly in medical imaging and protein-hormone systems. His current research is based on ultrasonographic, biochemical and computational study of thyroid disorders
Statement of the Problem: Routine assesment of thyroid status basically relies on ultrasonographic (USG) examinations and Thyroid Function Tests (TFT) determining the serum concentrations of FT3, FT4 and TSH. Along with finding the prevalence of hypothyroidism, it is required to explore the biophsical insights in the molecular levels behind such disorders. Methodology & Theoretical Orientation: USG and TFT measurements of the patients were performed at Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal. The mutational and overt hypothyroidal impacts on thyroid hormone receptors (THRs) were studied by nanoscale molecular dynamics simulations in a high performance computer at Central Department of Physics, TU, Nepal. Findings: The prevalences of subclinical and overt hypothyroidism are 64.58% and 11.73% of 963 hypothyroid subjects based on TFT results under the study of 4438 subjects. In a total of 140 patients (mean age: 38.94x13.60 years) perfroming both USG and TFT observations, 22.86 % have hypothyroidism (mean TSH: 25.86 mIU/L) with mean size of left and right lobe, 4.92x3.24 mL and 5.66x3.93 mL, respectively finding multinodular goiters, hypoechoic lesions, chronic thyroiditis, benign/malignant nodules, and colloid cysts in some patients. Negative correlation between FT3/ FT4 and TSH verifies the negative feedback mechanism of thyroid cycle. At overt hypothyroidism, THRs become free of T3 or T4 in their binding sites that reduce the gene transcription rate. By the molecular dynamics study of native stateTHRs, the heat capacity of T3 liganded THR-β is 9.76x0.38 kcal/mol/K and that of unliganded THR-β is 9.08x0.34 kcal/mol/K at 310 K. It makes change in heat transfer properties. Conclusion & Significance: In menarche and menopause periods, thyroid size of females is higer than that of males. Females are more vulnerable towards hypothyroidism. The mutated, T3-liganded and unliganded-THRs have the different structuaral and thermophysical properties like interaction energies, heat capacity, heat coduction and normal modes of vibrations.
Time : 11:30-12:00